The Best Diphenhydramine 2025

Updated On July 19th, 2025

Looking for the best Diphenhydramine? You aren't short of choices in 2022. The difficult bit is deciding the best Diphenhydramine for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Diphenhydramine.

Rank Product Name Score
1
Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Check Price
100%
2
KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

Check Price
100%
3
Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Check Price
98%
4
Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Check Price
98%
5
Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

Check Price
96%
6
KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

Check Price
94%
7
Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

Check Price
92%
8
Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz

Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol F

Check Price
0%
9
Wal-Dryl Allergy Dye Free / Diphenhydramine HCl / TABLET, FILM COATED

Wal-Dryl Allergy Dye Free / Diphenhydramine HCl / TABLET, FILM COATED

Check Price
0%
10
Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Check Price
0%

1. Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle
100%

Our Score

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle Diphenhydramine temporarily relieves symptoms caused by hay fever or other upper respiratory allergies: runny nose; sneezing; itchy, watery eyes; itching of the nose or throat. One of the most effective over-the-counter antihistamines, diphenhydramine is the generic version of Benadryl. Diphenhydramine can also be used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Like Benadryl, these diphenhydramine tablets will likely cause drowsiness. 1 Bottle(s), 100 Allergy Relief Bottle , 100 Total Count

There are 50 milligrams of diphenhydramine HCl in a capsule Compare to active ingredient in Benadryl® Extra Strength Allergy Relief Ultratabs® – a registered trademark of Kenvue Antihistamine is not a nondrowsy type so it is recommended you take before bedtime There are 100 capsules in a bottle

2. KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)
100%

Our Score

This allergy medicine temporarily relieves symptoms such as runny nose, sneezing, itching, watery eyes, and itching of the nose or throat. Please note that when using this product, marked drowsiness may occur. Excitability may also occur, especially in children

Diphenhydramine HCl 25 mg is for antihistamine and allergy relief. Temporarily relieves symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. It also relieves symptoms due to the common cold, such as runny nose and sneezing. This temporarily relieves symptoms from hay fever and upper respiratory allergies. Do not use with any other product containing diphenhydramine, even one used on skin.

3. Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets
98%

Our Score

Members Mark Diphenhydramine Antihistamine Tablets is used for the temporary relief of these symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itchy, watery eyes, itching of the nose or throat. Members Mark is dedicated providing healthful, gentle, and safe personal care products for the entire family. We continuously strive to be your partner in wellness and exceed your expectations.

Uses: Temporarily relieves symptoms from hay fever and upper respiratory allergies: Runny Nose, Sneezing, Itching, watery eyes, Itching of the nose or throat Active Ingredients (in each tablet) - Purpose: Diphenhydramine HCl 25 mg - Antihistamine. Warnings. Do not use: To make a child sleepy. With any other product containing diphenhydramine, even one used on skin.

4. Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.
98%

Our Score

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief. Product Features: For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the common cold Tablets are easy to swallow Adults take 1 or 2 tablets every 4 ' 6 hours; do not take more than 6 doses in 24 hours Product Warnings: Ask a doctor before use if you have glaucoma, trouble urinating due to an enlarged prostate gland or a breathing problem such as emphysema or chronic bronchitis When using this product, marked drowsiness may occur and excitability may occur, especially in children Avoid alcoholic drinks. Alcohol, sedatives and tranquilizers may increase drowsiness.

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief.Product Features:For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the

5. Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count
96%

Our Score

Kick your allergies to the curb with Equate Allergy Relief Tablets. Each individual tablet contains 25 mg of a powerful antihistamine that temporarily relieves runny nose, sneezing, itchy and watery eyes, and itching of the nose and throat due to seasonal allergies. Adults can take one to two tablets every four to six hours as symptoms persist, but are instructed not to exceed six doses within 24 hours. Children six to under twelve years can take one tablet every four to six hours but are instructed not to exceed six doses within 24 hours. Manage your allergies with Equate Allergy Relief Tablets. Making the right health decisions can be challenging. With a complete range of products and simple solutions, Equate allows you to take care of your family with confidence.

Temporarily relieves symptoms due to hay fever or respiratory allergies Can be used to treat common cold symptoms and allergy symptoms Ingredients may cause drowsiness Includes 365 tablets per bottle Can be taken by children ages 6 and up and adults

6. KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack
94%

Our Score

This allergy medicine temporarily relieves symptoms such as runny nose, sneezing, itching, watery eyes, and itching of the nose or throat. Please note that when using this product, marked drowsiness may occur. Excitability may also occur, especially in children

Diphenhydramine HCl 25 mg is for antihistamine and allergy relief. Temporarily relieves symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. It also relieves symptoms due to the common cold, such as runny nose and sneezing. This temporarily relieves symptoms from hay fever and upper respiratory allergies. Do not use with any other product containing diphenhydramine, even one used on skin.

7. Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult
92%

Our Score

Get effective, fast-acting relief from indoor and outdoor allergies with Santo Remedio Diphenhydramine Allergy Relief Tablets. Each tablet contains 25 mg of Diphenhydramine HCl, an antihistamine trusted to relieve common allergy symptoms such as sneezing, runny nose, itchy throat, and watery eyes. This powerful formula can also be used as a nighttime sleep aid when occasional sleeplessness is caused by allergies. With 100 tablets per bottle, this allergy relief solution offers long-lasting value and dependable support whenever symptoms strike.

Santo Remedio Diphenhydramine Allergy Relief Tablets are made to relieve allergy symptoms Alleviates runny nose, itchy eyes, and sneezing, so you can get back to enjoying your day Easy to store in your medicine cabinet, desk, car, and purse Take 1 caplet every 4-6 hours while symptoms persist All ingredients have been tested to ensure true identity, purity, and strength Each bottle contains 100 tablets with standard 25 Mg of diphenhydramine per tablet Santo Remedio is a complete and natural range of health product Counts developed by renowned physician Dr. Juan Rivera Adult

8. Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz

Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz
0%

Our Score

LEADER Kids Allergy Medicine provides relief from multiple symptoms at the same time like runny nose, sneezing, itchy watery eyes, itching of the nose or throat, associated with seasonal allergies or hay fever. LEADER Children's Allergy Medicine has an alcohol-free formula that is safe for young kids to consume without adverse side effects. Please bear in mind some drowsiness may occur when using this item. Do not combine with other Diphenhydramine products, even on skin. LEADER Diphenhydramine Liquid provides a respite from allergies for 4-6 hours, when taken as directed on the package. Use only enclosed dosing cap specifically designed for this item. Do not use another dosing device. Active ingredient (in each 5 mL): Diphenhydramine HCl 12.5 mg. NDC Code(s): 70000-0474-1

TARGET MULTIPLE SYMPTOMS: LEADER Kids Allergy Medicine provides relief from multiple symptoms at the same time like runny nose, sneezing, itchy watery eyes, itching of the nose or throat, associated with seasonal allergies or hay fever. ALCOHOL-FREE: LEADER Children's Allergy Medicine has an alcohol-free formula that is safe for young kids to consume without adverse side effects. Please bear in mind some drowsiness may occur when using this item. Do not combine with other Diphenhydramine products, even on the skin. 4-6 HOURS OF ALLERGY RELIEF: LEADER Diphenhydramine Liquid provides a respite from allergies for 4-6 hours when taken as directed on the package. Use only the enclosed dosing cap specifically designed for this item. Do not use another dosing device. Please read the instructions carefully before ingesting. CHERRY FLAVOR: LEADER Diphenhydramine Liquid Kids comes in a kid-friendly cherry flavor, which even the pickiest little ones won’t detect its medicine. Available in Bubble Gum flavor as well. Certified Gluten Free. Do not use it to make a child sleepy. SAFE FOR KIDS 6-11: LEADER Liquid Benadryl Kids Generic is suitable for kids ages 6 to 11. Administer 5-10 ml every 4 to 6 hours. Do not use on children ages 2-5 unless directed by a doctor. Not intended for young infants. If any allergies occur please discontinue application immediately.

9. Wal-Dryl Allergy Dye Free / Diphenhydramine HCl / TABLET, FILM COATED

Wal-Dryl Allergy Dye Free / Diphenhydramine HCl / TABLET, FILM COATED
0%

Our Score

Active Ingredients: DIPHENHYDRAMINE HYDROCHLORIDE 25mg

Wal-Dryl Allergy Dye Free / Diphenhydramine HCl / TABLET, FILM COATED

10. Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count
0%

Our Score

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count


arrow_upward