The Best Enfamil Enspire 2025

Updated On July 21st, 2025

Looking for the best Enfamil Enspire? You aren't short of choices in 2022. The difficult bit is deciding the best Enfamil Enspire for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Enfamil Enspire.

Rank Product Name Score
1
Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 20.5 Oz Tub, 4 Count

Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 20.5 Oz Tub, 4 Count

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96%
2
Enfamil Optimum Powder Baby Formula, Our Closest to Breast Milk, 30 oz Box, 4 count

Enfamil Optimum Powder Baby Formula, Our Closest to Breast Milk, 30 oz Box, 4 count

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96%
3
Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz

Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting

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96%
4
Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz

Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting

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96%
5
Enfamil Enspire Gentlease Powder Baby Formula, With Lactoferrin Reduces Fussiness, Crying, Gas & Spit-up, 29 Oz Box

Enfamil Enspire Gentlease Powder Baby Formula, With Lactoferrin Reduces Fussiness, Crying, Gas & Spit-up, 29 Oz Box

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94%
6
Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 29 Oz Box, 4 Count

Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 29 Oz Box, 4 Count

Check Price
94%

1. Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 20.5 Oz Tub, 4 Count

Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 20.5 Oz Tub, 4 Count
96%

Our Score

Enfamil Enspire Baby Formula with iron is an inspired way to nourish. Enspire has MFGM and Lactoferrin for brain support, two key components found in breast milk, making it our closest infant formula ever to breast milk. Lactoferrin is a protein found in colostrum and breast milk that provides immune support and intestinal development, and MFGM has been shown to support mental development. Enspire is a non-GMO milk powder baby formula that is designed to provide Complete nutrition, with omega 3 DHA, Choline, and our proprietary blend of probiotics, for babies through 12 months. Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources. QuintilesIMS, using the ProVoice Survey fielded from Janurary 2017 to December 31, 2017.

OUR CLOSEST FORMULA TO BREAST MILK: Enspire Optimum is Enfamil’s closest formula to breast milk with lactoferrin, found in colostrum + breast milk, and Dual HMOs PROTEIN YOUR BABY NEEDS: Enspire Optimum has lactoferrin; an important protein in breast milk + colostrum that aids in iron absorption and supports baby’s immune system EXCLUSIVE HuMO6 IMMUNE BLEND: Formula designed from breast milk with key components, such as 2’-FL HMO, LNnT HMO, Vitamin C, Vitamin E, Zinc, and Selenium PEACE OF MIND: Enspire Optimum has NO artificial growth hormones, NO artificial colors or flavors, and NON-GMO, designed for complete nutrition for babies through 12 months TRUSTED BY PARENTS & PEDIATRICIANS*: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians* & Parents and the #1 Trusted Brand for Brain-Building & Immune Support SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits https://www.walmart.com/m/brands/enfamil

2. Enfamil Optimum Powder Baby Formula, Our Closest to Breast Milk, 30 oz Box, 4 count

Enfamil Optimum Powder Baby Formula, Our Closest to Breast Milk, 30 oz Box, 4 count
96%

Our Score

Enfamil Enspire Infant Formula is an inspired way to nourish. Enspire has MFGM and Lactoferrin, two key components found in breast milk, making it our closest formula ever to breast milk. Enspire is a non-GMO† baby formula that is designed to provide complete nutrition for babies through 12 months.†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.**Enfamil is the #1 pediatrician recommended brand of Infant Formula - QuintilesIMS, using the ProVoice Survey fielded from October 1, 2016 to September 30, 2017.

OUR CLOSEST FORMULA TO BREAST MILK: Enspire Optimum is Enfamil’s closest formula to breast milk with lactoferrin, found in colostrum + breast milk, and Dual HMOs PROTEIN YOUR BABY NEEDS: Enspire Optimum has lactoferrin; an important protein in breast milk + colostrum that aids in iron absorption and supports baby’s immune system EXCLUSIVE HuMO6 IMMUNE BLEND: Formula designed from breast milk with key components, such as 2’-FL HMO, LNnT HMO, Vitamin C, Vitamin E, Zinc, and Selenium PEACE OF MIND: Enspire Optimum has NO artificial growth hormones, NO artificial colors or flavors, and NON-GMO, designed for complete nutrition for babies through 12 months TRUSTED BY PARENTS & PEDIATRICIANS*: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians* & Parents and the #1 Trusted Brand for Brain-Building & Immune Support SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits

3. Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz

Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz
96%

Our Score

Enfamil Enspire Gentlease Infant Formula is an inspired way to nourish. Enspire Gentlease has MFGM and Lactoferrin, two key components found in breast milk, making it our closest formula ever to breast milk. Lactoferrin is a protein found in colostrum and breast milk that supports the immune system and intestinal development, and MFGM has been shown to support mental development. Enspire is a non-GMO† baby formula that is designed to provide complete nutrition for babies through 12 months.†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.*QuintilesIMS, using the ProVoice Survey fielded from Janurary 2017 to December 31, 2017.

NEW LOOK, UPDATED FORMULA: Enfamil Optimum Gentlease, formerly Enspire Gentlease, has a fresh new look and an improved formula designed for your little one’s comfort OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum Gentlease is the first and only leading brand with lactoferrin (also found in colostrum and breast milk) and has dual HMOs for optimal immune support found in Colostrum that supports the immune system PREMIUM IMMUNE BLEND: Now has a dual prebiotic blend (2'FL & LnNT), key ingredients naturally present in breastmilk to support baby's developing immune system PEACE OF MIND: Optimum contains NO artificial growth hormones, NO artificial colors or flavors, and is NON-GMO, offering complete nutrition for babies through 12 months. TRUSTED BY PARENTS & PEDIATRICIANS*: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians* & Parents and the #1 Trusted Brand for Brain-Building & Immune Support

4. Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz

Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz
96%

Our Score

Introducing Enfamil Optimum Gentlease, formerly known as Enfamil Enspire Gentlease—now with a fresh new look and an advanced formula. Designed to be our closest formula to breast milk with gentle nutrition, Optimum Gentlease is specially formulated to ease fussiness, crying, and gas in just 24 hours, making it ideal for babies with sensitive tummies. It has lactoferrin, a key protein also found in colostrum and breast milk, to support immune health and gut health. Optimum Gentlease has 2'FL & LnNT, two of the most abundant HMOs that are naturally present in breastmilk, to nourish their immune health. With NO artificial growth hormones, NO artificial colors or flavors, and a NON-GMO† formula, Enfamil Optimum Gentlease has complete nutrition for babies through 12 months. Give your baby the best start with Enfamil—trusted by parents*, backed by science. †Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources. *Among those who have a preference; Based on the 2023 survey by AMC Global.

NEW LOOK, UPDATED FORMULA: Enfamil Optimum Gentlease, formerly Enspire Gentlease, has a fresh new look and an improved formula designed for your little one’s comfort OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum Gentlease is the first and only leading brand with lactoferrin (also found in colostrum and breast milk) and has dual HMOs for optimal immune support EASY-TO-DIGEST PROTEINS: Gentle formula, specially formulated to help ease fussiness, crying, gas and spit-up in 24 hours. PREMIUM IMMUNE BLEND: Now has a dual prebiotic blend (2'FL & LnNT), key ingredients naturally present in breastmilk to support baby's developing immune system PEACE OF MIND: Optimum contains NO artificial growth hormones, NO artificial colors or flavors, and is NON-GMO, offering complete nutrition for babies through 12 months. TRUSTED BY PARENTS & PEDIATRICIANS*: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians* & Parents and the #1 Trusted Brand for Brain-Building & Immune Support

5. Enfamil Enspire Gentlease Powder Baby Formula, With Lactoferrin Reduces Fussiness, Crying, Gas & Spit-up, 29 Oz Box

Enfamil Enspire Gentlease Powder Baby Formula, With Lactoferrin Reduces Fussiness, Crying, Gas & Spit-up, 29 Oz Box
94%

Our Score

Enfamil Enspire Gentlease Infant Formula is an inspired way to nourish. Enspire Gentlease has MFGM and Lactoferrin, two key components found in breast milk, making it our closest formula ever to breast milk. Lactoferrin is a protein found in colostrum and breast milk that supports the immune system and intestinal development, and MFGM has been shown to support mental development. Enspire is a non-GMO† baby formula that is designed to provide complete nutrition for babies through 12 months.†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.*QuintilesIMS, using the ProVoice Survey fielded from Janurary 2017 to December 31, 2017.

FIRST AND ONLY FORMULA: With lactoferrin, also found in breast milk + colostrum, to support immune health ALL IN ONE COMFORT: Enfamil Enspire Gentlease is scientifically formulated to help ease fussiness, crying, gas and spit-up in 24 hours BRAIN BUILDING AND IMMUNE SUPPORT: DHA has been shown to support brain development and Lactoferrin is a protein found in Colostrum that supports the immune system EASY-TO-DIGEST GENTLE PROTEINS: Designed to be easy for developing digestive systems to digest NON-GMO: Enspire is a non-GMO baby formula that is designed to provide complete nutrition for babies through 12 months #1 TRUSTED BRAND: Enfamil is the #1 Trusted Brand for Brain-building & Immune Support PEDIATRICIAN RECOMMENDED: Enfamil is the #1 infant formula brand recommended by pediatricians SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits https://www.walmart.com/m/brands/enfamil

6. Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 29 Oz Box, 4 Count

Enfamil Enspire Optimum Powder Baby Formula, With Lactoferrin, Our Closest Formula to Breast Milk, 29 Oz Box, 4 Count
94%

Our Score

Enfamil Enspire Gentlease Infant Formula is an inspired way to nourish. Enspire Gentlease has MFGM and Lactoferrin, two key components found in breast milk, making it our closest formula ever to breast milk. Lactoferrin is a protein found in colostrum and breast milk that supports the immune system and intestinal development, and MFGM has been shown to support mental development. Enspire is a non-GMO† baby formula that is designed to provide complete nutrition for babies through 12 months.†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.*QuintilesIMS, using the ProVoice Survey fielded from Janurary 2017 to December 31, 2017.

FIRST AND ONLY FORMULA: With lactoferrin, also found in breast milk + colostrum, to support immune health ALL IN ONE COMFORT: Enfamil Enspire Gentlease is scientifically formulated to help ease fussiness, crying, gas and spit-up in 24 hours BRAIN BUILDING AND IMMUNE SUPPORT: DHA has been shown to support brain development and Lactoferrin is a protein found in Colostrum that supports the immune system EASY-TO-DIGEST GENTLE PROTEINS: Designed to be easy for developing digestive systems to digest NON-GMO: Enspire is a non-GMO baby formula that is designed to provide complete nutrition for babies through 12 months #1 TRUSTED BRAND: Enfamil is the #1 Trusted Brand for Brain-building & Immune Support PEDIATRICIAN RECOMMENDED: Enfamil is the #1 infant formula brand recommended by pediatricians SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits https://www.walmart.com/m/brands/enfamil


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