Updated On May 21st, 2025
Looking for the best Omeprazole? You aren't short of choices in 2022. The difficult bit is deciding the best Omeprazole for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Omeprazole.
Rank | Product Name | Score | |
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1 |
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Good Sense Omeprazole Delayed Release, Acid Reducer Tablets 20 mg 28 ea
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100%
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2 |
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Equate Omeprazole Delayed-Release Acid Reducer Capsules 20mg, 14 Count
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96%
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3 |
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Equate Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, Frequent Heartburn, 28 Count
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96%
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4 |
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Good Sense Omeprazole Delayed Release, Acid Reducer Tablets 20 mg 42 ea
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94%
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5 |
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Equate Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, Frequent Heartburn, 14 Count
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94%
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6 |
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GoodSense Omeprazole Delayed Release, Acid Reducer Tablets 20 mg, 14 Count
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88%
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7 |
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(2 pack) (2 Pack) Prilosec OTC Frequent Heartburn Medicine and Acid Reflux Reducer Tablets 42 Count - Omeprazole - Proton Pump Inh
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0%
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8 |
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Perrigo Omeprazole Delayed Release Tablets, 20mg 28 ea
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0%
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9 |
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***Discontinued***Equaline Omeprazole 20mg, 28 CT (Pack of 6)
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0%
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10 |
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***Discontinued***Equaline Omeprazole 20mg, 42 CT (Pack of 3)
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0%
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Our Score
Treats the same symptoms as Prilosec OTC Acid Reducer Treats Frequent Heartburn, occurring 2 or More Days a Week Two 14-day courses of treatment May take 1 to 4 days for full effect
Good Sense Free Shipping Sold Individually
Our Score
Equate Omeprazole Delayed-Release 20 mg Capsules are an effective over-the-counter medication which provides relief for frequent heartburn (occurring two or more days a week). Take one capsule daily to treat heartburn for up to 24 hours. The active ingredient, Omeprazole, is an acid reducer that works by inhibiting the proton pumps in the stomach from producing excess acid, effectively reducing stomach acid at its source. (Compare to the active ingredient in Prilosec OTC® 24-hour heartburn relief) For adults 18 years of age and older. Use as directed for 14 days; do not take for more than 14 days or more often than every four months unless directed by a doctor. These capsules are not for immediate relief: May take one to four days for full effect; see package label for warnings and other important information. Get the relief you need with Equate Omeprazole Delayed-Release 20 mg Capsules. Making the right health decisions can be challenging. With a complete range of products and simple solutions, Equate allows you to take care of your family with confidence.
Treats frequent heartburn that occurs 2 or more days a week Up to 24-hour relief for adults 18 years of age and older Omeprazole works by inhibiting the proton pumps in the stomach, preventing them from producing excess acid. May take 1 to 4 days for full effect Compare to the active ingredient in Prilosec OTC®
Our Score
Compare to Prilosec OTC. Stop the painful burning sensation of frequent heartburn before it begins with Equate Omeprazole Delayed Release Tablets 20 mg. Omeprazole is the #1 Active Ingredient for Frequent Heartburn (based on iRi sales volume among PPI products sold in the United States, for the 52 weeks ending 01/01/23). When used as directed for 14 days, Omeprazole prevents heartburn that is frequent in nature and provides long-lasting, 24-hour relief so you can enjoy every moment with family and friends. This heartburn medicine may take one to four days for full effect, although some people get complete relief of symptoms within 24 hours. Proton Pump Inhibitors (PPIs), like Omeprazole, work differently from antacid tablets and other acid reducer pills. These heartburn relief treatments only neutralize the stomach acid and provide shorter relief (less than 24 hours). Omeprazole stops acid production at the source, preventing the acid that causes heartburn symptoms for relief that lasts all day and night. This heartburn medicine is a 14-day course of treatment that should be taken once every 24 hours for 14 days to treat frequent heartburn flare-ups. For adults 18 years and older suffering from frequent heartburn that occurs two or more days a week.
#1 Active Ingredient: Omeprazole is the #1 Active Ingredient for Frequent Heartburn (based on iRi sales volume among PPI products sold in the United States, for the 52 weeks ending 01/01/23). Compare to Prilosec OTC. 24-Hour Relief: Heartburn happens when stomach acid refluxes into the esophagus, causing uncomfortable heartburn symptoms. When taken as directed, this 24-hour treatment helps to relieve the painful burning sensation of frequent heartburn symptoms. Frequent Heartburn Relief: For frequent heartburn that occurs two or more days a week, take once every 24 hours for 14 days. This heartburn medicine is not intended for immediate relief of heartburn and may take one to four days for full effect. Physician Recommended: Omeprazole is a PPI, the #1 Physician Recommended type of OTC acid reducer (of U.S. physicians surveyed by an independent market research firm); FSA/HSA eligible. Proton Pump Inhibitor (PPI): Each dose of Omeprazole deactivates pumps in the stomach lining to inhibit acid production (and its overproduction) at the source.
Our Score
reats the same symptoms as Prilosec OTC Acid Reducer Treats Frequent Heartburn, occurring 2 or More Days a Week Three 14-day courses of treatment May take 1 to 4 days for full effect
GOOD SENSE OMPRZ RLS TBLT ACD RDCR BOX ANTACID ANTIGAS AND DIGESTIVE AID
Our Score
Compare to Prilosec OTC. Stop the painful burning sensation of frequent heartburn before it begins with Equate Omeprazole Delayed Release Tablets 20 mg. Omeprazole is the #1 Active Ingredient for Frequent Heartburn (based on iRi sales volume among PPI products sold in the United States, for the 52 weeks ending 01/01/23). When used as directed for 14 days, Omeprazole prevents heartburn that is frequent in nature and provides long-lasting, 24-hour relief so you can enjoy every moment with family and friends. This heartburn medicine may take one to four days for full effect, although some people get complete relief of symptoms within 24 hours. Proton Pump Inhibitors (PPIs), like Omeprazole, work differently from antacid tablets and other acid reducer pills. These heartburn relief treatments only neutralize the stomach acid and provide shorter relief (less than 24 hours). Omeprazole stops acid production at the source, preventing the acid that causes heartburn symptoms for relief that lasts all day and night. This heartburn medicine is a 14-day course of treatment that should be taken once every 24 hours for 14 days to treat frequent heartburn flare-ups. For adults 18 years and older suffering from frequent heartburn that occurs two or more days a week.
#1 Active Ingredient: Omeprazole is the #1 Active Ingredient for Frequent Heartburn (based on iRi sales volume among PPI products sold in the United States, for the 52 weeks ending 01/01/23). Compare to Prilosec OTC. 24-Hour Relief: Heartburn happens when stomach acid refluxes into the esophagus, causing uncomfortable heartburn symptoms. When taken as directed, this 24-hour treatment helps to relieve the painful burning sensation of frequent heartburn symptoms. Frequent Heartburn Relief: For frequent heartburn that occurs two or more days a week, take once every 24 hours for 14 days. This heartburn medicine is not intended for immediate relief of heartburn and may take one to four days for full effect. Physician Recommended: Omeprazole is a PPI, the #1 Physician Recommended type of OTC acid reducer (of U.S. physicians surveyed by an independent market research firm); FSA/HSA eligible. Proton Pump Inhibitor (PPI): Each dose of Omeprazole deactivates pumps in the stomach lining to inhibit acid production (and its overproduction) at the source.
Our Score
Omeprazole from GoodSense is an acid reducer in a delayed release tablet that is not intended for immediate relief of heartburn. It may take 1 to 4 days for the full effect.
EFFECTIVE: Compare GoodSense Omeprazole Delayed Release Tablets 20 mg to Prilosec OTC. The active ingredient in these delayed release tablets is Omeprazole 20 mg. It works as an acid reducer to treat frequent heartburn. TREATS FREQUENT HEARTBURN: These acid reducer pills treat frequent heartburn that occurs 2 or more times a week. ACID REDUCER: Omeprazole 20 mg is a Proton Pump Inhibitor PPI that deactivates pumps in the stomach lining to inhibit acid production at the source. 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect. TIPS FOR MANAGING HEARTBURN: Do not lie flat or bend over soon after eating. Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods.
Our Score
-Prilosec OTC provides heartburn treatment for frequent heartburn that occurs 2 or more days a week. 24 hours of heartburn relief. -Prilosec OTC is the first and original OTC frequent heartburn medicine. -One pill each morning.24 hours. Zero heartburn.* *It's possible while taking Prilosec OTC.
Prilosec OTC Frequent Heartburn Medicine and Acid Reducer Tablets, 42 Count - Omeprazole - Proton Pump Inhibitor - PPI: #1 Doctor** recommended OTC frequent heartburn treatment medicine for 10 straight years. #1 Gastroenterologist^ recommended OTC frequent heartburn medicine for 10 straight years. #1 Pharmacist^^ recommended OTC frequent heartburn medicine for 10 straight years.
Our Score
What is this drug used for? It is used to treat heartburn.It may be given to you for other reasons. Talk with the doctor.
Treats Frequent Heartburn!28 TabletsTwo 14-Day Courses of Treatment100% Satisfaction GuaranteedIndications: treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect
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