The Best Tylenol 2025

Updated On July 8th, 2025

Looking for the best Tylenol? You aren't short of choices in 2022. The difficult bit is deciding the best Tylenol for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Tylenol.

Rank Product Name Score
1
Tylenol Arthritis Pain Reliever 650 mg 100 Caplet

Tylenol Arthritis Pain Reliever 650 mg 100 Caplet

Check Price
92%
2
Tylenol Light + Heat Therapy Drug-Free Knee Pain Relief Kit, 6 Items

Tylenol Light + Heat Therapy Drug-Free Knee Pain Relief Kit, 6 Items

Check Price
78%
3
Tylenol Light + Heat Therapy Drug-Free Back & Hip Pain Relief Kit, 6 Items

Tylenol Light + Heat Therapy Drug-Free Back & Hip Pain Relief Kit, 6 Items

Check Price
76%
4
Product of Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct.

Product of Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct.

Check Price
0%
5
Tylenol Acetaminophen, 500mg, Extra Strength Caplets, Refill, 2 /Packet, 30 Packs/Box (97477)

Tylenol Acetaminophen, 500mg, Extra Strength Caplets, Refill, 2 /Packet, 30 Packs/Box (97477)

Check Price
0%
6
Tylenol Extra Strength - 4 Caplets Case Pack 12

Tylenol Extra Strength - 4 Caplets Case Pack 12

Check Price
0%
7
Tylenol 8-Hour Arthritis Pain Extended-Release Tablets, 650mg, 290 Count

Tylenol 8-Hour Arthritis Pain Extended-Release Tablets, 650mg, 290 Count

Check Price
0%
8
Extra Strength Tylenol 500mg Acetaminophen Pain Reliever Caplet 487348

Extra Strength Tylenol 500mg Acetaminophen Pain Reliever Caplet 487348

Check Price
0%
9
Tylenol Drug-Free Light + Heat Therapy Knee Refill Gel Pads

Tylenol Drug-Free Light + Heat Therapy Knee Refill Gel Pads

Check Price
0%
10
Quality Choice Non Aspirin Extra Strength 500mg 100 Caplets Each

Quality Choice Non Aspirin Extra Strength 500mg 100 Caplets Each

Check Price
0%

1. Tylenol Arthritis Pain Reliever 650 mg 100 Caplet

Tylenol Arthritis Pain Reliever 650 mg 100 Caplet
92%

Our Score

Tylenol 8 HR Arthritis Pain Extended Release Caplets temporarily relieves the minor pain of arthritis. With 650 milligrams of acetaminophen per caplet, this pain medicine also temporarily relieves aches and pains associated with muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, and toothache. From Tylenol, the #1 doctor-recommended brand of pain relievers, these caplets also temporarily reduce fever. The bi-layer design delivers fast-acting relief that lasts up to eight hours.

Temporarily relieves minor arthritis pain as well as other aches and pains 650 milligrams of acetaminophen per caplet Fast-acting relief lasts up to eight hours Bi-layer caplet design

2. Tylenol Light + Heat Therapy Drug-Free Knee Pain Relief Kit, 6 Items

Tylenol Light + Heat Therapy Drug-Free Knee Pain Relief Kit, 6 Items
78%

Our Score

Tylenol Light + Heat Therapy Knee Pain Relief Kit provides relief from knee pain. The pain relief kit includes a cordless wrap device, a rechargeable controller, two sets of adhesive gel pads, one storage pouch and 1 charging cable. The drug-free pain relief device uses red and infrared light driven heat therapy to provide targeted pain relief directly where it hurts. This cordless device increases local circulation to direct oxygen and nutrients in your body to the site of pain without interfering with your daily activities and is designed to be form-fitting so it moves with your body. Tylenol Light + Heat Therapy is not a TENS device and does not contain acetaminophen, so it’s 100% drug-free. This pain relief kit is designed to be used for up to two 30-minute sessions per day and also includes a free download for a companion app where you can watch a video on how to use your device, set up reminders to fit therapy into your schedule, and receive exclusive offers!

Cordless device for knee pain relief using light plus heat at the site of pain Provides drug-free pain relief that does not contain acetaminophen or an NSAID Temporarily relieves pain, relaxes muscles, soothes joints, and increases local circulation Light-based heat therapy reduces the sensation of knee pain by activating thermal receptors Wearable pain relief device moves with your body as you go about regular activities Each treatment lasts 15 minutes & can be repeated once for a total of 30 minutes before recharging Includes device, rechargeable controller, 2 sets of adhesive gel pads, 1 pouch, & 1 charging cable Free companion app allows you to set reminders, get exclusive offers, and more

3. Tylenol Light + Heat Therapy Drug-Free Back & Hip Pain Relief Kit, 6 Items

Tylenol Light + Heat Therapy Drug-Free Back & Hip Pain Relief Kit, 6 Items
76%

Our Score

Tylenol Light + Heat Therapy Back & Hip Pain Relief Kit provides temporary relief from hip and back pain. The back pain relief kit includes a cordless wrap device, a rechargeable controller, two sets of adhesive gel pads, one storage pouch, and one charging cable. The drug-free pain relief device uses red and infrared light driven heat therapy to provide targeted pain relief. This cordless device increases local circulation to direct oxygen & nutrients in your body to the site of pain without interfering with your daily activities and is designed to be form-fitting so it moves with your body. Tylenol Light + Heat Therapy is not a TENS device and does not contain acetaminophen, so it’s 100% drug-free. This pain relief kit is designed to be used for up to two 30-minute sessions per day and also includes a free download for a companion app where you can watch a video on how to use your device, set up reminders to fit therapy into your schedule, and receive exclusive offers!

Cordless device for back & hip pain relief using light plus heat at the site of pain Offers drug-free back & hip pain relief that is both NSAID- and acetaminophen-free Temporarily relieves pain, relaxes muscles, soothes joints, and increases local circulation Light-based heat therapy reduces muscle and joint pain by activating thermal receptors Wearable pain relief device moves with your body as you go about regular activities Each treatment lasts 15 minutes &can be repeated once for a total of 30 minutes before recharging Includes device, rechargeable controller, 2 sets of adhesive gel pads, 1 pouch, & 1 charging cable Free companion app allows you to set reminders, get exclusive offers, and more

4. Product of Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct.

Product of Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct.
0%

Our Score

Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct., Tylenol Rapid Release Gels provide temporary relief of fever and minor aches and pains, including headache, backache, minor pain of arthritis, toothaches, pain due to the common cold, premenstrual and menstrual cramps. Each gelcap contains 500 milligrams of acetaminophen, a pain reliever. The Rapid Release gelcaps feature laser-drilled holes to facilitate fast medicine release, , Product Features:, , Provides temporary pain relief for minor aches and pains and reduces feverContains 500mg acetaminophen per gelcapEffective in providing minor headache relief, backache reliefGelcaps feature laser-drilled holes for quick medicine releaseIncludes 290 ct., (Model 48890), Product Features:Provides temporary pain relief for minor aches and pains and reduces feverContains 500mg acetaminophen per gelcapEffective in providing minor headache relief, backache reliefGelcaps feature laser-drilled holes for quick medicine releaseIncludes 290 ct., (Model 48890)

Product of Tylenol Rapid Release Gels, Fever Reducer and Pain Reliever, 500 mg, 290 ct.

5. Tylenol Acetaminophen, 500mg, Extra Strength Caplets, Refill, 2 /Packet, 30 Packs/Box (97477)

Tylenol Acetaminophen, 500mg, Extra Strength Caplets, Refill, 2 /Packet, 30 Packs/Box (97477)
0%

Our Score

Works fast to relieve headache pain. Wont upset your stomach. Reduces fever. Smooth, easy-to-swallow caplets. Packaged for quick refill of Lil' Drugstore Medicine Dispensers (sold separately) or for other use. Contains: 30 pouches of 2 tablets; Description: Tylenol Extra Strength Caplets, 2/Pack; For Use With: Lil' Drugstore Display Dispenser LIL71613 or LIL71615.#1 Doctor Recommended OTC Medicine that works fast to relieve pain and fever, headache, backache,minor arthritis pain, toothache, muscular aches, premenstrual and menstrual cramps.Provides single dose in sanitary pouch for safety.Packaged for quick refill of Lil' Drugstore display dispenser (sold separately) or for other use.Increases productivity on the workplace by keeping staff productive and at their station.Refills fit the Lil' Drugstore Medicine Dispensers. Package Includes 30 packets of two caplets each Tylenol Extra Strength

#1 Doctor Recommended OTC Medicine that works fast to relieve pain and fever, headache, backache,minor arthritis pain, toothache, muscular aches, premenstrual and menstrual cramps.Provides single dose in sanitary pouch for safety.Packaged for quick refill of Lil' Drugstore display dispenser (sold separately) or for other use. Tylenol Acetaminophen, 500mg, Extra Strength Caplets, Refill, 2 /Packet, 30 Packs/Box (97477)

6. Tylenol Extra Strength - 4 Caplets Case Pack 12

Tylenol Extra Strength - 4 Caplets Case Pack 12
0%

Our Score

Acetaminophen is used to treat minor aches and pain and to reduce fever. It may also help treat pain from mild forms of arthritis. Pain Relief Fever Reducer Acetaminophen 4 CT Caplets Case Pack 12 Please note: If there is a color/size/type option, the option closest to the image will be shipped (Or you may receive a random color/size/type). SKU:SUZ35349859

Tylenol Extra Strength - 4 Caplets - CASE OF 144

7. Tylenol 8-Hour Arthritis Pain Extended-Release Tablets, 650mg, 290 Count

Tylenol 8-Hour Arthritis Pain Extended-Release Tablets, 650mg, 290 Count
0%

Our Score

Tylenol 8-Hour Arthritis Pain Tablets stop the pain quickly. The 650mg acetaminophen caplets temporarily give relief caused by minor arthritis. It also helps reduce pain caused by backaches, headaches and cold symptoms. These Tylenol tablets come in a 290-count bottle that is ideal for keeping at home, in the car or the office.

Tylenol 8-Hour Arthritis Pain Extended-Release Tablets, 650mg, 290 Count: Stops the pain quickly 650mg acetaminophen caplets Temporarily gives relief caused by minor arthritis pain Resealable cap Good for traveling or for your desk drawer at the office or medicine cabinet at home Stops pain caused by backache, headaches and cold symptoms 290-count bottle of arthritis tablets, extended release

8. Extra Strength Tylenol 500mg Acetaminophen Pain Reliever Caplet 487348

Extra Strength Tylenol 500mg Acetaminophen Pain Reliever Caplet 487348
0%

Our Score

Extra strength pain relief caplets temporarily reduce fever and relieves minor aches and pains.Extra strength pain relief caplets temporarily reduce fever and relieves minor aches and pains. With 500 mg of acetaminophen per caplet, they provide pain relief from headache, backache and pre-menstrual and menstrual cramps. 50-count, Pack of 2 of Tylenol Extra Strength Caplets with acetaminophen to provide temporary relief of minor aches and pains and help reduce fever. Each extra strength caplet contains 500 mg of acetaminophen for effective, lasting pain relief, and has an excellent safety profile when used as directed. Use as a fever reducer and to help alleviate common pain symptoms including headache, backache, toothache, menstrual cramps and pain caused by the common cold. This oral pain reliever can be used by adults and children who are 12 years and older. From the #1 doctor-recommended brand of pain relievers, experience relief from minor aches and pains with Tylenol. An essential item for your breakroom or supply closet. Safety Data Sheet.Tylenol Extra Strength caplets help reduce fever and provide temporary relief of minor aches and pains. From the #1 doctor-recommended brand of pain reliever, each caplet contains 500 mg of acetaminophen for effective, extra strength pain relief. Both a fever reducer and pain reliever, it relieves minor aches and pains due to headache, backache, toothache, minor pain of arthritis, the common cold, and premenstrual and menstrual cramps. When used as directed, it has an excellent safety profile and can be used by adults and children 12 years and older. Sold as 50/Box.

Sold as 50/Box. 50-count, Pack of 2 of Tylenol Extra Strength Caplets with acetaminophen to provide temporary relief of minor aches and pains and help reduce fever. From the #1 doctor-recommended brand of pain relievers, experience relief from minor aches and pains with Tylenol. Safety Data Sheet. Each extra strength caplet contains 500 mg of acetaminophen for effective, lasting pain relief, and has an excellent safety profile when used as directed. An essential item for your breakroom or supply closet. Use as a fever reducer and to help alleviate common pain symptoms including headache, backache, toothache, menstrual cramps and pain caused by the common cold. This oral pain reliever can be used by adults and children who are 12 years and older.

9. Tylenol Drug-Free Light + Heat Therapy Knee Refill Gel Pads

Tylenol Drug-Free Light + Heat Therapy Knee Refill Gel Pads
0%

Our Score

Designed for use with the Tylenol Light + Heat Therapy Knee Pain Relief Kit, these adhesive gel pads help keep the cordless device in place to provide targeted knee pain relief. The reusable gel pads work with the drug-free device (sold separately) to provide red and infrared light driven heat therapy directly at the site of pain for sore and aching knees. These gel pads should be replaced seven days after opening or when they become dirty, damaged, or lose adhesiveness. This package contains two gel pad refills.

Pain relief gel pads for use with Tylenol Light + Heat Therapy Knee Pain Relief Kit; Gel pads allow the cordless, form-fitting device to stay in place; Device temporarily relieves knee pain, relaxes muscles, and soothes joints; Device provides knee pain therapy and increases local circulation to site of pain; Device offers knee pain relief that is both drug- and acetaminophen-free; Contains two adhesive gel pad refills; reusable for multiple applications; Replace pads 7 days after opening or when they're dirty, damaged, or lose adhesiveness; Wearable gel pad moves with your body as you go about regular activities

10. Quality Choice Non Aspirin Extra Strength 500mg 100 Caplets Each

Quality Choice Non Aspirin Extra Strength 500mg 100 Caplets Each
0%

Our Score

N/A

Quality Choice Non Aspirin Extra Strength 500mg 100 Caplets Each


arrow_upward