The Best Diphenhydramine 2025

Updated On July 30th, 2025

Looking for the best Diphenhydramine? You aren't short of choices in 2022. The difficult bit is deciding the best Diphenhydramine for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Diphenhydramine.

Rank Product Name Score
1
Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

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100%
2
Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

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100%
3
Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

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98%
4
Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

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98%
5
(3 pack) (3 pack) Equate Allergy Relief Diphenhydramine Antihistamine Capsules, 25 mg, 100 Ct

(3 pack) (3 pack) Equate Allergy Relief Diphenhydramine Antihistamine Capsules, 25 mg, 100 Ct

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96%
6
Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

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96%
7
KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

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94%
8
Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

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92%
9
GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itch

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82%
10
Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

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0%

1. Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle
100%

Our Score

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle Diphenhydramine temporarily relieves symptoms caused by hay fever or other upper respiratory allergies: runny nose; sneezing; itchy, watery eyes; itching of the nose or throat. One of the most effective over-the-counter antihistamines, diphenhydramine is the generic version of Benadryl. Diphenhydramine can also be used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Like Benadryl, these diphenhydramine tablets will likely cause drowsiness. 1 Bottle(s), 100 Allergy Relief Bottle , 100 Total Count

There are 50 milligrams of diphenhydramine HCl in a capsule Compare to active ingredient in Benadryl® Extra Strength Allergy Relief Ultratabs® – a registered trademark of Kenvue Antihistamine is not a nondrowsy type so it is recommended you take before bedtime There are 100 capsules in a bottle

2. Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle
100%

Our Score

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle Get effective relief from your allergies with Geri-Care Diphenhydramine Allergy Relief – antihistamine relief in a small tablet that works against the most powerful allergens. Diphenhydramine will also mitigate symptoms of motion sickness 1 Bottle(s), 1000 Allergy Relief Bottle , 1000 Total Count

Antihistamine 25 mg diphenhydramine hydrochloride per tablet Compare to active ingredient in Benadryl® Allergy Ultratab® – a registered trademark of Kenvue. 1,000 ultra-small tablets per bottle

3. Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets
98%

Our Score

Members Mark Diphenhydramine Antihistamine Tablets is used for the temporary relief of these symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itchy, watery eyes, itching of the nose or throat. Members Mark is dedicated providing healthful, gentle, and safe personal care products for the entire family. We continuously strive to be your partner in wellness and exceed your expectations.

Uses: Temporarily relieves symptoms from hay fever and upper respiratory allergies: Runny Nose, Sneezing, Itching, watery eyes, Itching of the nose or throat Active Ingredients (in each tablet) - Purpose: Diphenhydramine HCl 25 mg - Antihistamine. Warnings. Do not use: To make a child sleepy. With any other product containing diphenhydramine, even one used on skin.

4. Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.
98%

Our Score

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief. Product Features: For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the common cold Tablets are easy to swallow Adults take 1 or 2 tablets every 4 ' 6 hours; do not take more than 6 doses in 24 hours Product Warnings: Ask a doctor before use if you have glaucoma, trouble urinating due to an enlarged prostate gland or a breathing problem such as emphysema or chronic bronchitis When using this product, marked drowsiness may occur and excitability may occur, especially in children Avoid alcoholic drinks. Alcohol, sedatives and tranquilizers may increase drowsiness.

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief.Product Features:For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the

5. (3 pack) (3 pack) Equate Allergy Relief Diphenhydramine Antihistamine Capsules, 25 mg, 100 Ct

(3 pack) (3 pack) Equate Allergy Relief Diphenhydramine Antihistamine Capsules, 25 mg, 100 Ct
96%

Our Score

Allergies can hit you anytime and anywhere. Rely on 25mg Equate Allergy Relief Capsules to get you the relief you need to feel better fast. They provide temporary relief of symptoms due to hay fever or other respiratory allergies and the common cold. They contain an active ingredient, diphenhydramine HCI, that works quickly to reduce the flow of liquid from your nose, sneezing, itchy, watery eyes and an itchy throat. This runny nose medicine is available in a convenient 100-count bottle. Making the right health decisions can be challenging. With a complete range of products and simple solutions, Equate allows you to take care of your family with confidence.

Equate Allergy Medication 25mg Capsules Antihistamine, 100-Count: Temporarily relieves symptoms due to hay fever or other respiratory allergies and the common cold such as: a runny nose, sneezing, itchy, watery eyes and an itchy throat Each capsule individually banded for your protection Active ingredient (in each banded capsule): diphenhydramine HCl 25mg antihistamine Compare to Benadryl's active ingredient Common cold medicine, 100-count bottle

6. Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count

Equate Allergy Relief Tablets with Diphenhydramine Hcl 25mg Antihistamine, 365 Count
96%

Our Score

Kick your allergies to the curb with Equate Allergy Relief Tablets. Each individual tablet contains 25 mg of a powerful antihistamine that temporarily relieves runny nose, sneezing, itchy and watery eyes, and itching of the nose and throat due to seasonal allergies. Adults can take one to two tablets every four to six hours as symptoms persist, but are instructed not to exceed six doses within 24 hours. Children six to under twelve years can take one tablet every four to six hours but are instructed not to exceed six doses within 24 hours. Manage your allergies with Equate Allergy Relief Tablets. Making the right health decisions can be challenging. With a complete range of products and simple solutions, Equate allows you to take care of your family with confidence.

Temporarily relieves symptoms due to hay fever or respiratory allergies Can be used to treat common cold symptoms and allergy symptoms Ingredients may cause drowsiness Includes 365 tablets per bottle Can be taken by children ages 6 and up and adults

7. KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack
94%

Our Score

This allergy medicine temporarily relieves symptoms such as runny nose, sneezing, itching, watery eyes, and itching of the nose or throat. Please note that when using this product, marked drowsiness may occur. Excitability may also occur, especially in children

Diphenhydramine HCl 25 mg is for antihistamine and allergy relief. Temporarily relieves symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. It also relieves symptoms due to the common cold, such as runny nose and sneezing. This temporarily relieves symptoms from hay fever and upper respiratory allergies. Do not use with any other product containing diphenhydramine, even one used on skin.

8. Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 mg, 100 Count, Adult
92%

Our Score

Get effective, fast-acting relief from indoor and outdoor allergies with Santo Remedio Diphenhydramine Allergy Relief Tablets. Each tablet contains 25 mg of Diphenhydramine HCl, an antihistamine trusted to relieve common allergy symptoms such as sneezing, runny nose, itchy throat, and watery eyes. This powerful formula can also be used as a nighttime sleep aid when occasional sleeplessness is caused by allergies. With 100 tablets per bottle, this allergy relief solution offers long-lasting value and dependable support whenever symptoms strike.

Santo Remedio Diphenhydramine Allergy Relief Tablets are made to relieve allergy symptoms Alleviates runny nose, itchy eyes, and sneezing, so you can get back to enjoying your day Easy to store in your medicine cabinet, desk, car, and purse Take 1 caplet every 4-6 hours while symptoms persist All ingredients have been tested to ensure true identity, purity, and strength Each bottle contains 100 tablets with standard 25 Mg of diphenhydramine per tablet Santo Remedio is a complete and natural range of health product Counts developed by renowned physician Dr. Juan Rivera Adult

9. GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies
82%

Our Score

✅ BULK SAVINGS BOTTLE - Stop worrying about constant refills or late night allergy attacks with no pills on hand. Our 1000 count bottle is the perfect size for families or people who suffer from chronic indoor and outdoor allergies. Easy to swallow tablet ✅ ITCHY EYE RELIEF - Experience fast relief from itchy, puffy, red or watery eyes typically caused by pet dander, hair, pollen, dust and hay fever. You don't have to suffer through allergy symptoms another day longer. Itchy eyes can negatively affect your vision, focus and even work performance. ✅ BETTER BREATHING - Diphenhydramine HCL helps reduce and relieve congestion of your nose, sinus and throat to help you breathe better and deeper. The antihistamine effects of this over the counter medication can help reduce the symptoms of the common cold like a runny nose, coughing or sneezing. ✅ MORE RESTFUL SLEEP - Allergy symptoms can make your whole day miserable, but they can also affect your sleep. The antihistamine response may naturally cause drowsiness in both adults and kids, so it is often taken in the evening or before bed to help you fall asleep faster and stay asleep. ✅ 100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 1000 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of allergy symptom free customers...Click Add-to-Cart Today!

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

10. Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count
0%

Our Score

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count


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