The Best Over-the-Counter Medicines 2025

1. Equate Infants' Pain Relief Suspension Drops Grape Flavor Fever Reducer/Pain Reliever 1 Oz

 

 

2. Cramer Red Hot Ointment, Muscle & Joint Pain Relief, 1 Pound Jar

This is the real deal, a maximum strength warming pain reliever used by college and professional athletes. Contains the active ingredient oleoresin capsicum for maximum warmth for muscle soreness, joint pain, arthritis pain and more. Incorporates a comfortable terrycloth interior treated with an antimicrobial agent to help keep the brace clean and odor-free. Use the rest of your hand while immobilizing the MCP joint, wear when sleeping.

Loosens tight muscles prior to workout, and soothes aches afterwards, popular with athletes who play hockey, rugby, basketball, football, tennis and many other high impact sports Use after working physically intense jobs like construction or demolition, or after a long day working in the yard

3. Vivarin Caffeine Alertness Aid 200 mg Tablets, 40 Ea

Vivarin Caffeine Alertness Aid 40 Tablets (Each)

Vivarin Caffeine Alertness Aid 200 Mg Tablets, 40 Ea Manufacturer_part_number: 346017018400 Manufacturer: GlaxoSmithKline Gtin: 00353100186311

4. Bayer Consumer Care Alka Seltzer Plus Cold Medicine, 48 ea

Cold Medicine, Sparkling Original Flavor Effervescent Tablets 48 tablets Nasal decongestant, antihistamine, analgesic. Relieves runny nose, nasal congestion, headache, body aches and sneezing. Provides temporary relief of these major symptoms of colds and flu: runny nose, nasal and sinus congestion, headache, body aches and pains, sneezing, fever and sore throat. Adults and children 12 years and older: Take two tablets fully dissolved in 4 ounces of water (use more or less water to taste). Repeat every 4 hours, not to exceed 8 tablets in any 24-hour period or as directed by a doctor. Children under 12 years of age: consult a doctor. You don't have to drink the residue on the sides or bottom of the glass. All the medicines are in the water. Children and teenagers should not use this medicine for chicken pox or flu symptoms before a doctor is consulted about Reye syndrome, a rare but serious illness reported to be associated with aspirin. Do not take this product for more than 7 days or for fever for more than 3 days unless directed by a doctor. If symptoms, including pain or fever, persist, do not improve or get worse, if new symptoms occur, or if redness or swelling is present, consult a doctor because these could be signs of a serious condition. If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea or vomiting, consult a doctor promptly. Do not exceed recommended dosage. If nervousness, dizziness or sleeplessness occur, discontinue use and consult a doctor. May cause excitability especially in children. Do not take this product unless directed by a doctor if you are allergic to aspirin, have a breathing problem such as emphysema or chronic bronchitis, have asthma, glaucoma, heart disease, high blood pressure, thyroid disease, diabetes, stomach problems that persist or recur, ulcers or bleeding problems, or difficulty in urination due to enlargement of the prostate gland or are on a sodium restricted diet. Each tablet contains 506 mg of sodium. If ringing in the ears or loss of hearing occurs, consult a doctor before taking any more of this product. May cause drowsiness; alcohol, sedatives and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages while taking this product. Do not take this product if you are taking sedatives or tranquilizers without first consulting a doctor. Use caution when driving a motor vehicle or operating machinery. Keep this and all drugs out of the reach of children. In case of accidental overdose, seek professional assistance or contact a poison control center immediately. As with any drug, if you are pregnant or nursing a baby, seek the advice of a health professional before using this product. It is especially important not to use aspirin during the last 3 months of pregnancy unless specifically directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Alcohol Warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take aspirin or other pain relievers/fever reducers. Aspirin may cause stomach bleeding. 48 tablets Morristown, NJ 07960 800-800-4793

This item contains regulated materials and is available only via Ground shipping, which takes up to 8 business days (We're sorry, Priority and Express shipping are not available for this item). Read more about Shipping & Returns Alka-Seltzer Plus® Cold Medicine Original Flavor gives you fast, effective relief from: Runny Nose Nasal Congestion Headaches Body Aches Sneezing

5. Novartis Consumer Slow Fe 30 Count

Slow FE slow-release iron with its unique controlled-delivery system gives you the high-potency iron you need with the gentleness you want. Clinically shown to reduce the side effects of constipation and abdominal discomfort common to iron use. Contains ferrous sulfate, the ingredient most recommended by doctors. Easy on the system.

Supplement Facts Serving Size: 1 Tablet Iron 50 mg 277 % Daily Value

6. Equate Low Dose Aspirin 120-count

Each Equate Adult Low Dose Enteric Safety Coated Aspirin Tablet provides 81 mg. of aspirin to temporarily relieve minor aches and pains. Use as recommended by your doctor. Ask your doctor about important, new uses for low-dose aspirin. Each tablet contains 81 mg. 120 Count

Use as recommended by your doctor, ask your doctor about important, new uses for low-dose

7. Equate Natural Vegetable Powder, Orange Flavor

Natural vegetable powder, as a part of high-fiber therapy, acts as a laxative and bowel normalizer to give pain relief from irritable bowel syndrome and hemorrhoids.

Helps reduce high cholesterol levels Relieves constipation

8. Equate: Oxymetazoline Hydrochloride 0.05% Nasal Decongestant/Extra Moisturizing/12 Hour Nasal Spray, 1 oz

 

Quality Guaranteed Temporarily Relieves Nasal Congestion Due to Common Cold, Hay Fever, Upper Respiratory Allergies. Shrinks Swollen Nasal Membranes So You Can Breathe More Freely Compare to Afrin Extra Moisturizing Nasal Spray Active Ingredient

9. Equate Infant Pain Relief

10. Pepcid AC Acid Reducer, 10 mg 30ct.

Pepcid AC Acid Reducer prevents and relieves heartburn due to acid indigestion with just one tablet (read package insert before use). Pepcid AC prevents heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages.

Pepcid: Original Strength Gelcaps Ac Acid Reducer, 30 ct