The Best Similac for Sensitive Tummies Baby Formula (Sensitive, Soy, Spit-up, Total Comfort) 2025

Updated On May 1st, 2025

Looking for the best Similac for Sensitive Tummies Baby Formula (Sensitive, Soy, Spit-up, Total Comfort)? You aren't short of choices in 2022. The difficult bit is deciding the best Similac for Sensitive Tummies Baby Formula (Sensitive, Soy, Spit-up, Total Comfort) for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Similac for Sensitive Tummies Baby Formula (Sensitive, Soy, Spit-up, Total Comfort).

Rank Product Name Score
1
Similac For Spit-Up Infant Formula With Iron, 12.5-oz Can, Pack of 6

Similac For Spit-Up Infant Formula With Iron, 12.5-oz Can, Pack of 6

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86%
2
Similac Sensitive Powder Baby Formula, 22.5-oz Tub

Similac Sensitive Powder Baby Formula, 22.5-oz Tub

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84%
3
Similac Sensitive Powder Baby Formula, 22.5-oz Tub, Pack of 6

Similac Sensitive Powder Baby Formula, 22.5-oz Tub, Pack of 6

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84%
4
Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle, Pack of 6

Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle, Pa

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84%
5
Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle

Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle

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82%
6
Similac Pro-Sensitive Powder Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

Similac Pro-Sensitive Powder Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

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82%
7
Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can, Pack of 4

Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can, Pack of 4

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82%
8
Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

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82%
9
Similac For Spit-Up Infant Formula with Iron, Ready-to-Feed, 1 qt (4-Pack)

Similac For Spit-Up Infant Formula with Iron, Ready-to-Feed, 1 qt (4-Pack)

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68%

1. Similac For Spit-Up Infant Formula With Iron, 12.5-oz Can, Pack of 6

Similac For Spit-Up Infant Formula With Iron, 12.5-oz Can, Pack of 6
86%

Our Score

Similac For Spit-Up infant formula has been clinically shown to reduce spit-up frequency in healthy infants by 54%.[1,*] Our non-GMO,§ easy-to-digest formula is suitable for babies with lactose sensitivity. It has our exclusive blend of DHA, lutein, and vitamin E to support brain and eye development and no palm olein oil, which allows for excellent calcium absorption. Similac is the #1 brand chosen by parents and the first infant formula brand with no artificial growth hormones. * Among healthy 2-month-old infants, compared to standard milk-based formula. Total US infant formula, all outlets as of 12/2019, Nielsen data. No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. § Ingredients not genetically engineered. Reference: 1. Lasekan JB, et al. J Am Coll Nutr. 2014;33(2):136-146.,in select stores, The SNAP (Supplemental Nutrition Assurance Program) name is a service mark of the U.S. Department of Agriculture. USDA does not endorse any goods, services, or enterprises.

6 CANS: Make sure you don’t run out; get 6 cans that make approximately 132 4-fl-oz bottles EASY TO DIGEST: Similac For Spit-Up infant formula is easy to digest and suitable for babies with lactose sensitivity REDUCES SPIT-UP BY 54%: Made with rice starch and clinically shown to reduce spit-up frequency in healthy infants by 54%[1,*] SUPPORTS BRAIN & EYES: Has an exclusive blend of DHA, lutein, and vitamin E and no palm olein oil for excellent calcium absorption MIXING TIPS: The rice starch in this formula mixes more slowly & may look “grainy;” this is normal & shouldn’t affect feeding Accepting SNAP EBT on Grocery Pick Up for this Item

2. Similac Sensitive Powder Baby Formula, 22.5-oz Tub

Similac Sensitive Powder Baby Formula, 22.5-oz Tub
84%

Our Score

Similac Sensitive* is an easy-to-digest, milk-based infant formula designed for sensitive tummies. It’s complete nutrition for fussiness,† gas,† or mild spit-up. Our formula has our exclusive blend of nutrients to help support baby’s brain and eye development. Similac was the first leading infant formula brand with no artificial growth hormones‡ and is the #1 infant formula brand fed in hospitals. * Not for infants or children with galactosemia. † Due to lactose sensitivity. ‡ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

DESIGNED FOR BABY’S FUSSINESS† & GAS†: Our sensitive formula for babies is specially designed for fussiness and gas due to lactose sensitivity SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Designed to support excellent calcium absorption PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‡: Similac was the first leading infant formula brand with no artificial growth hormones

3. Similac Sensitive Powder Baby Formula, 22.5-oz Tub, Pack of 6

Similac Sensitive Powder Baby Formula, 22.5-oz Tub, Pack of 6
84%

Our Score

Similac Sensitive* is an easy-to-digest, milk-based infant formula designed for sensitive tummies. It’s complete nutrition for fussiness,† gas,† or mild spit-up. Our formula has our exclusive blend of nutrients to help support baby’s brain and eye development. Similac was the first leading infant formula brand with no artificial growth hormones‡ and is the #1 infant formula brand fed in hospitals. * Not for infants or children with galactosemia. † Due to lactose sensitivity. ‡ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

DESIGNED FOR BABY’S FUSSINESS† & GAS†: Our sensitive formula for babies is specially designed for fussiness and gas due to lactose sensitivity SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Designed to support excellent calcium absorption PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‡: Similac was the first leading infant formula brand with no artificial growth hormones

4. Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle, Pack of 6

Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle, Pack of 6
84%

Our Score

Similac Pro-Sensitive* infant formula is designed for babies with sensitive tummies who have fussiness and gas due to lactose sensitivity. It has 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk, that supports baby’s developing immune system. * Not for infants or children with galactosemia. † Not from human milk. ‡ At significant levels. § Due to lactose sensitivity. ‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. ¶ Ingredients not genetically engineered

FORMULA FOR SENSITIVE TUMMIES: Gentle nutrition designed to ease common tummy troubles like fussiness, gas, or mild spit-up.§ Suitable for infants with lactose sensitivity 2’FL HMO PREBIOTIC FOR IMMUNE SUPPORT: Similac Pro-Sensitive has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Has no palm olein oil to support excellent calcium absorption for strong bones PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Pro-Sensitive contains ingredients that are not genetically engineered

5. Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle

Similac Pro-Sensitive Ready-to-Feed Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 32-fl-oz Bottle
82%

Our Score

Similac Pro-Sensitive* infant formula is designed for babies with sensitive tummies who have fussiness and gas due to lactose sensitivity. It has 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk, that supports baby’s developing immune system. * Not for infants or children with galactosemia. † Not from human milk. ‡ At significant levels. § Due to lactose sensitivity. ‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. ¶ Ingredients not genetically engineered

FORMULA FOR SENSITIVE TUMMIES: Gentle nutrition designed to ease common tummy troubles like fussiness, gas, or mild spit-up.§ Suitable for infants with lactose sensitivity 2’FL HMO PREBIOTIC FOR IMMUNE SUPPORT: Similac Pro-Sensitive has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Has no palm olein oil to support excellent calcium absorption for strong bones PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Pro-Sensitive contains ingredients that are not genetically engineered

6. Similac Pro-Sensitive Powder Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

Similac Pro-Sensitive Powder Baby Formula for Lactose Sensitivity, With 2’-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4
82%

Our Score

Similac Pro-Sensitive* infant formula is designed for babies with sensitive tummies who have fussiness and gas due to lactose sensitivity. It has 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk, that supports baby’s developing immune system. * Not for infants or children with galactosemia. † Not from human milk. ‡ At significant levels. § Due to lactose sensitivity. ‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. ¶ Ingredients not genetically engineered

FORMULA FOR SENSITIVE TUMMIES: Gentle nutrition designed to ease common tummy troubles like fussiness, gas, or mild spit-up.§ Suitable for infants with lactose sensitivity 2’FL HMO PREBIOTIC FOR IMMUNE SUPPORT: Similac Pro-Sensitive has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Has no palm olein oil to support excellent calcium absorption for strong bones PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Pro-Sensitive contains ingredients that are not genetically engineered

7. Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can, Pack of 4

Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can, Pack of 4
82%

Our Score

Similac Pro-Total Comfort* is a gentle formula with 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk that supports baby’s developing immune system. Comfort your baby’s fussiness and gas§ with Similac Pro-Total Comfort—it has an easy-to-digest blend of carbohydrates that’s gentle on your baby’s tummy. * Not for infants or children with galactosemia. † Not from human milk. ‡ At significant levels. § Due to lactose sensitivity. || Milk ingredients are derived from milk of non-rbST-treated cows, which is not different from milk of rbST-treated cows. ¶ Ingredients not genetically engineered.

Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can, Pack of 4 Partially hydrolyzed whey protein to help with easy digestion Our most gentle formula that has a prebiotic for immune support Has DHA and lutein to support brain & eye development No palm olein oil supports excellent calcium absorption for strong bones Available in convenient ready-to-feed formula Similac is the #1 infant formula brand fed in hospitals No artificial growth hormones‡ & non-GMO§

8. Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4

Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub, Pack of 4
82%

Our Score

Similac Pro-Total Comfort* is a gentle formula with 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk that supports baby’s developing immune system. It’s an easy-to-digest formula for babies with fussiness, gas, and crying who have difficulty tolerating other milk-based formulas.* Not for infants or children with galactosemia.† Not from human milk.‡ At significant levels.§ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.‖ Ingredients not genetically engineered.

Partially hydrolyzed whey protein promotes easy digestion Our most gentle formula with prebiotic for immune support Has DHA and lutein to support brain & eye development No palm olein oil supports excellent calcium absorption for strong bones Similac is the #1 infant formula brand fed in hospitals No artificial growth hormones§ & non-GMO‖

9. Similac For Spit-Up Infant Formula with Iron, Ready-to-Feed, 1 qt (4-Pack)

Similac For Spit-Up Infant Formula with Iron, Ready-to-Feed, 1 qt (4-Pack)
68%

Our Score

Similac for Spit-Up Infant Formula is specially formulated with rice starch and is clinically shown to reduce spit-up in healthy infants by 54%*. Our baby formula includes OptiGRO, our exclusive blend of DHA, Lutein and Vitamin E to help support your baby's overall growth, brain, eye and immune system development. *Reduced frequency among 2 month old healthy infants compared to a standard milk-based formula (Lasekan JB et al. J Am Coll Nutr. 2014;33(2):136-146)

Similac is the first infant formula brand with no artificial growth hormone (no significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows) Similac for spit-up Infant Formula is a nutritionally complete formula specially formulated with rice starch and clinically shown to reduce spit-up in healthy infants by 54%* Not for infants and children with galactosemia) NUTRIENTS: Features OptiGRO, our exclusive blend of DHA, Lutein and Vitamin E, special nutrients found in breast milk that are important for helping support baby's brain and eye development Because of the rice starch, our baby formula mixes a little more slowly with water and may look more "grainy" than other Similac formulas. This is not a product defect and should not cause an issue when feeding through a nipple


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